P2X7 Receptor Upregulation in Huntington’s Disease Brains

Applying Bioinfomatics Strategies in Huntingtons Disease Research

The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease.

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, on immune cells. P2X7 activation results in a number of downstream events, including the release of proinflammatory mediators and cell death and proliferation. As such, P2X7 plays important roles in various inflammatory, immune, neurologic and musculoskeletal disorders. This review focuses on the ...

Significance of P2X7 receptor variants to human health and disease.

The human P2X7 receptor is a trimeric ligand-gated cation channel coded by the P2XR7 gene located at chromosome position 12q24. P2X7 is expressed in a wide variety of normal and disease-associated cell types. Activation of this receptor by extracellular adenosine 5'-triphosphate results in numerous downstream events including the release of pro-inflammatory mediators, cell proliferation or deat...

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

Upregulation of glial clusterin in brains of patients with AIDs.

Since clusterin (CLU) production in reactive astrocytes may be neuroprotective, we examined its distribution in AIDS brains where brain injury and reactive astrocytosis are common. The relative area and number of CLU-positive astrocytes, as well as their percent total of all white matter glia, significantly increased in AIDS brains with and without HIV encephalitis (P<0.05). Proliferation marke...